INTRODUCTION
BDG LifeSciences is a distinguished bioinformatics company established in 2010 and operates globally. Headquartered in India the company specializes in facilitating workshops, training programs, novel & innovative research projects, and online courses in technologies of bioinformatics & life science. The company is registered under the Ministry of MSME (Micro, Small, and Medium Enterprises), Government of India, with the registration number UDYAM-UP-01-0019151. Recently, BDG Lifesciences, India has authorized BBR Group Pty Ltd., Australia (ACN 608 550 849), to operate its programs in Australia & New Zealand.
With a focus on practical application of technology, where participants work on their own computer/laptop on software/servers, BDG LifeSciences has been a leader in the sector for the last 14 years. Since its inception, BDG LifeSciences has successfully educated a diverse range of participants globally, including students, scientists, faculty members, professors, and corporate executives.
Innovation & Creativity is the core part of BDG Lifesciences and as per the increasing demand advancing in the technology we have launched a 5-day Online Technical Training in Computational Epigenetics. It will be an extensive 5-day training program in which every day 120 minutes interactive training sessions will be conducted to give the user a unique learning experience. VIDEO RECORDING WILL BE PROVIDED. On successful completion of the course participation certificate will be awarded.
Delve into the exciting field of Computational Epigenetics with this 5-day hands-on training program. Explore epigenetic mechanisms such as DNA methylation, histone modifications, chromatin accessibility, and non-coding RNAs. Gain practical skills in data analysis, integration, and visualization using advanced bioinformatics tools to investigate gene regulation and epigenetic influences on health and disease.
Course Overview
TOPICS/MODULES COVERED IN THIS TRAINING: This training focuses on computational methods for analyzing and interpreting epigenomic data. Participants will learn to process datasets from technologies like bisulfite sequencing, ChIP-seq, and ATAC-seq, and integrate them with transcriptomic data to uncover epigenetic insights into biological systems.
Introduction to Epigenetics and Computational Epigenomics
- Fundamentals of Epigenetics: DNA methylation, histone modifications, chromatin accessibility, and non-coding RNAs.
- Overview of epigenomic technologies: Bisulfite sequencing, ChIP-seq, ATAC-seq, and RNA-seq.
- Basics of computational epigenetics: Understanding raw data formats, preprocessing steps, and pipelines.
DNA Methylation Analysis
- Principles of DNA methylation and its role in gene regulation.
- Data processing workflows: Quality control, alignment, and methylation calling (using Bismark and other tools).
- Visualization and interpretation: Identifying differentially methylated regions (DMRs) and their biological significance.
Histone Modifications and Chromatin Accessibility
- Role of histone modifications in gene regulation and chromatin dynamics.
- Analyzing ChIP-seq data: Peak calling, annotation, and enrichment analysis.
- Chromatin accessibility analysis using ATAC-seq data: Preprocessing, peak detection, and foot-printing.
Personalized Drug Discovery and Treatment Optimization
- AI in identifying patient-specific therapeutic targets.
- Precision dosing and pharmacogenomics.
- Tools for designing individualized treatment plans.
Non-Coding RNA and Epigenetic Regulation
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- Role of microRNAs and long non-coding RNAs (lncRNAs) in epigenetic regulation.
- Computational pipelines for identifying and analyzing non-coding RNAs.
- Integration of non-coding RNA data with other epigenomic datasets.
Epigenomic Data Integration and Functional Interpretation
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- Combining multiple epigenomic datasets for holistic understanding (e.g., methylation, histone marks, and transcriptomics).
- Visualization and annotation of integrated epigenomic data using tools like IGV and UCSC Genome Browser.
- Case studies: Epigenetics in cancer, developmental biology, and personalized medicine.
Practical Application
DNA Methylation Analysis
Tools:
- Bismark: For alignment and methylation calling from bisulfite sequencing data.
- R/Bioconductor Packages (methylKit, DSS): For differential methylation analysis.
Servers/Platforms: Local computational setup or high-performance computing clusters (HPC).
Histone Modification Analysis
Tools:
- MACS2: For ChIP-seq peak calling.
- ChIPseeker: For annotating and visualizing ChIP-seq peaks.
- deepTools: For comparative analysis of histone marks.
Servers/Platforms:
- Galaxy Server for ChIP-seq workflows.
- UCSC Genome Browser for data visualization.
Chromatin Accessibility Analysis
Tools:
- ATAC-seq Pipeline (via ENCODE guidelines): For preprocessing and peak calling.
- HOMER: For motif analysis and transcription factor binding prediction
Servers/Platforms:
Cloud platforms like DNAnexus or AWS for large-scale ATAC-seq datasets.
Non-Coding RNA Analysis
Tools:
- STAR/RSEM: For alignment and quantification of RNA-seq data.
- miRDeep2: For microRNA discovery and profiling.
- lncFinder: For functional annotation of lncRNAs.
Servers/Platforms: GENCODE or miRBase for annotation databases.
Epigenomic Data Integration and Visualization
Tools:
- IGV (Integrative Genomics Viewer): For multi-omics data visualization.
- Circos: For creating circular genome plots.
- TIGER: For integrative analysis of epigenetic and transcriptomic data.
Servers/Platforms: UCSC Genome Browser and WashU Epigenome Browser for public epigenomic datasets.
Learning Objectives
OUTCOME [WHAT PEOPLE WILL LEARN]:
By the end of this training, participants will:
Understand the Foundations of Epigenetics:
- Grasp the key concepts of DNA methylation, histone modifications, chromatin accessibility, and non-coding RNAs.
- Comprehend how these mechanisms influence gene regulation and cellular function in health and disease.
Analyze DNA Methylation Data:
- Perform quality control, alignment, and methylation calling using bisulfite sequencing data.
- Identify and interpret differentially methylated regions (DMRs) and their biological relevance.
Explore Histone Modifications and Chromatin Accessibility:
- Process and analyzeChIP-seq data to identify histone modification patterns and transcription factor binding sites.
- Analyze ATAC-seq data to uncover chromatin accessibility dynamics and DNA-binding motifs.
Investigate Non-Coding RNAs:
- Profile microRNAs and long non-coding RNAs (lncRNAs) from sequencing data.
- Explore their regulatory roles and integrate them into broader epigenomic landscapes.
Integrate and Visualize Multi-Omics Data:
- Combine epigenomic, transcriptomic, and genomic datasets for a comprehensive understanding of biological systems.
- Use visualization tools like IGV, Circos, and UCSC Genome Browser to create meaningful insights.
Apply Computational Workflows:
- Gain hands-on experience with cutting-edge bioinformatics tools and platforms like Bismark, MACS2, deepTools, and Galaxy.
- Navigate public databases and servers for epigenomic datasets.
Interpret Case Studies in Epigenetics:
- Analyze real-world datasets to understand the epigenetics of cancer, development, and disease progression.
- Develop skills for critical thinking and data-driven hypothesis generation.
Build a Foundation for Research and Career Growth:
- Develop expertise to apply computational epigenetics in academic, clinical, or industry research settings.
- Stay equipped for future advancements in personalized medicine and systems biology.
DURATION [IN DAYS & TIME SPENT FOR EVERYDAY SESSION]: 5 days ( 2hrs / day)
SYSTEM REQUIREMENT [LIST THE SYSTEM REQUIREMENT]:Laptop or PC with 4GB RAM
PRE-REQUISITES [LIST ANY PRIOR KNOWLEDGE REQUIRED]:Not needed
Target Audience
This training is ideal for:
1. Students
- Undergraduate, postgraduate, and Ph.D. candidates in bioinformatics, molecular biology, and related fields.
2. Academicians
- Educators and researchers working on epigenetics or multi-omics projects.
3. Industry Professionals:
- Biologists, data scientists, and healthcare researchers interested in computational epigenetics and its applications in medicine and biotechnology.
Methodology
Participants will engage in interactive lectures, hands-on exercises, and case study analyses. The program uses cutting-edge tools such as Bismark, MACS2, HOMER, and R-based packages for data preprocessing, analysis, and visualization.
Why You Should Attend
This training provides a comprehensive understanding of computational epigenetics, equipping participants with practical skills to analyze complex datasets. It offers insights into the latest tools and techniques for studying epigenetic mechanisms, essential for research and career growth in academic and industrial settings.
Why Choose BDG LifeSciences for this Training?
1. Experience and Credibility: BDG LifeSciences, with over 14 years of expertise, is a market leader in bioinformatics course training and trainings.
2. Global Reach: Programs are accessible by participants from all around the world, and the curriculum is customized to international standards.
3. Hands-On Learning: The emphasis on practical application ensures that participants may instantly apply their knowledge.
4. Expert Advice: With cutting-edge tools, expert trainers, and comprehensive content, we ensure a rich learning experience tailored to industry and academic needs.
How To Register
To secure your spot:
- Click on Register Now button and proceed.
- After registering, please email to info@bdglifesciences.com with your preferred start date and choose one of the following time slots: 6:30 AM–8:30 AM India time or 8:30 PM–10:30 PM India time.
- Kindly note that the time of the sessions will be 90-120 minutes every day.
- Once you register, please allow us 2-5 working days to make your training schedule, i.e. dates and time.
- For any further queries, feel free to email us at info@bdglifesciences.com
Previous Events & Testimonials
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T & C
- Please provide a GMAIL ID for registration as the recorded video session will be provided on YouTube. Kindly provide that email ID by which you use YouTube.
- Since the training is a one-on-one live session with a trainer on Zoom, you'll need to attend, allowing for practical hands-on learning, real-time explanations, and direct query resolution for a better learning experience.
- At the end of each session, you will receive a video recording, allowing you to review the steps as many times as needed to enhance your learning and master the topics and tasks.
- BDG Lifesceiences (OPC) Private Limited is registered under Ministry of MSME(Micro, Small and Medium Enterprises), Government of India with Registration Number:UDYAM-UP-01-0019151 hence the certificate will be provided of it. BBR Group Pty Ltd, Australia (ACN-Australian Company Number-608 550 849) has the franchisee of BDG Lifesciences to run its programs in Australia & New Zealand.
- The certificate will be issued as per the details which you will provide in the registration form while registering before payment.
- We want to make sure that you learn properly hence the training certificate will be given ONLY on successful completion of all the tasks given by the trainer.
- The certificates of all our Online programs are sent by email (softcopy) which has a unique barcode. You can take a print of that on heavy cardstock or photo paper and get it laminated if required.
- The registration is NON-REFUNDABLE and NON-TRANSFERABLE.
- BDG Lifesciences (OPC) Pvt. Ltd., India and BBR Group Pty Ltd Australia reserve the right of admission in all our programs.
- If you are removed or your registration is canceled then there will be no answer to that. We have our own reasons for such an act of ours. If we do not wish to give this training to any participant then we will refund their amount.
- You should also read the Terms & Conditions page as well as the FAQs page. For any assistance kindly chat with our AI Assistant BioBot on the website www.bdglifesciences.com
