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BDG LifeSciences' Research Project Training Program is a one-of-a-kind initiative designed to strengthen your profile and enhance career opportunities, whether for jobs or higher studies, by offering the chance to work on novel research projects using the latest technologies in bioinformatics. Since 2010, this program has addressed the critical need for high-quality publications by combining innovative teaching methods with practical applications. Conducted entirely online, it provides participants with the flexibility to choose session timings while saving on travel, accommodation, and food expenses. With over 88 research projects successfully completed and published at the international level, this program is ideal as a major or thesis project for final-year students or for those looking to advance their profiles.
Applications are now open for ONLY 4 SEATS in our 91st novel research project, titled "ImmunoSpatial Blueprint: Mapping Tumor-Immune Interactions in Triple-Negative Breast Cancer Using Spatial Transcriptomics" This project focuses on spatial transcriptomics-based analysis of tumor-immune interactions in triple-negative breast cancer, equipping undergraduates, graduates, and higher-degree holders with practical skills in spatial omics, hands-on experience with real cancer datasets, and valuable opportunities to generate publication-ready findings.
Triple-negative breast cancer (TNBC) is one of the most aggressive and difficult-to-treat subtypes of breast cancer, characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of therapeutic targets, combined with its high spatial and molecular heterogeneity, contributes to poor prognosis and limited treatment options. A critical challenge in TNBC research is understanding the tumor microenvironment (TME) and the intricate interactions between tumor and immune cells, which hold the key to developing more effective therapies.
This research project leverages Spatial Transcriptomics (ST)—a cutting-edge technology that profiles gene expression while preserving the spatial context of tissues. By analyzing publicly available TNBC ST datasets with advanced computational tools, participants will investigate spatial heterogeneity, map immune cell infiltration patterns, and uncover how different tumor regions communicate. The insights gained from this project may help in understanding tumor behavior, immune response, and identifying potential therapeutic strategies.
To investigate spatial heterogeneity and tumor-immune interactions in triple-negative breast cancer using spatial transcriptomics.
This project follows a structured, hands-on approach over 8-12 weeks using publicly available TNBC datasets:
Literature Review & Background
Understand TNBC biology and the foundations of Spatial Transcriptomics.
Data Acquisition & Preprocessing
Work with real spatial omics datasets using Seurat v5, STUtility, and other tools.
Histology-Gene Expression Integration
Map H&E images with gene expression data and annotate tissue regions.
Spatial Gene Expression Analysis
Identify spatially variable genes and tumor sub-regions.
Cell Type Deconvolution
Use tools like Cell2location to detect immune cell distribution.
Tumor-Immune Architecture Analysis
Correlate immune cells with gene expression and immune pathways.
Visualization & Reporting
Prepare plots, summaries, and scientific visualizations for presentation.
Training sessions will be conducted on ZOOM.
Stage 1: Biological Background and Literature Review
Outcome: Ability to define spatial research questions specific to TNBC
Stage 2: Data Acquisition and Preprocessing
Outcome: Prepared dataset for downstream spatial analysis
Stage 3: Image Integration and Annotation
Outcome: Tissue architecture mapped with gene expression data
Stage 4: Identification of Spatially Variable Genes (SVGs)
Outcome: Spatial gene signatures and regional heterogeneity identified
Stage 5: Cell Type Deconvolution
Outcome: Spatial map of immune and stromal cell distributions
Stage 6: Tumor-Immune Architecture Analysis
Outcome: Insights into immune spatial patterns and tumor-TME interactions
Stage 7: Scientific Communication and Reporting
Outcome: Enhanced skills in interpreting and communicating spatial omics results
Work on a real, high-impact cancer research problem
Learn to use cutting-edge bioinformatics tools
Build a portfolio-ready project for academic or job applications
Gain mentorship from experienced professionals
Certificate of Research Completion
Personalized Guidance & Q&A
Gain Publication-Ready Visuals
Access to Tools like Seurat, Giotto, Cell2location
Practical experience with spatial omics datasets
Enhance your resume/CV with project-based skills
Makes you stand out in research and biotech job applications
Adds value to your graduate school or PhD applications
Prepares you for roles in Bioinformatics, Genomics, Cancer Research, and AI in Medicine
Equips you with hands-on data analysis experience in a trending field.
BDG LifeSciences has been a leader in bioinformatics research training since 2010, offering high-quality programs that integrate current industry trends. With over 88 successfully completed projects published internationally, we ensure participants gain expertise, practical knowledge, and career-enhancing opportunities in a cost-effective and flexible online format.
Pioneers in Hands-On Bioinformatics Training with over a decade of experience
90 successful research projects delivered globally
Personalized mentorship, structured curriculum, and project-based learning
Trusted by thousands of researchers, students, and professionals worldwide
Affordable, accessible, and practical training with cutting-edge tools
The Research Project Training Program by BDG LifeSciences is not just a course but an investment in your future. The fee you pay guarantees unparalleled value, providing you with cutting-edge skills, real-world experience, and the opportunity to contribute to internationally published research. This program is designed to elevate your academic and professional profile, equipping you with expertise in bioinformatics and drug discovery that is highly sought after in today’s competitive job market.
By participating, you gain the chance to learn from seasoned experts, work on innovative projects, and create a strong foundation for careers in bioinformatics, pharmaceutical research, or higher education. The program’s comprehensive structure ensures you receive everything you need to succeed—training, practical application, resources, certifications, and networking opportunities.
Whether you aim to pursue advanced studies, secure a high-impact job, or become a leader in your field, this program opens doors to new possibilities and heights of success. With BDG LifeSciences, you are not just learning—you are building a future where your contributions to science and technology can make a real difference.
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TEAM FOR CURRENT/ONGOING RESEARCH PROJECTS
91. ImmunoSpatial Blueprint: Mapping Tumor-Immune Interactions in Triple-Negative Breast Cancer Using Spatial Transcriptomics
90. Single-cell RNA-seq Analysis of Chemotherapy-Induced Transcriptomic Changes in Pancreatic Ductal Adenocarcinoma (PDAC)
88. Computational Insights into Selective ERβ Agonists for Benign Prostatic Hyperplasia (BPH) Treatment | A Virtual Screening, Molecular Docking & Simulations Study.
87. Decoding Pan-Cancer Pathogenesis: A Multi-Layered Analysis of Prognostic mRNAs, miRNAs, lncRNAs via Co-Expression Networks and PPINs
86. Unveiling Autoimmune Genes and Regulatory Elements in Head and Neck Squamous Cell Carcinoma through Advanced Machine Learning and Network-Based Analysis
85. Molecular Modeling study of derivatives of Leaf Extracts of medicinal plant Solanum torvum and Serine/Threonine Kinase from Mycobacterium Tuberculosis
84. Targeting Tumor Progression: Identifying Differentially Expressed Genes and Pathways in Pancreatic Ductal Adenocarcinoma using RNAseq
83. Next Generation Sequencing | Unraveling the Cancer Code: Gene Expression Profiling with RNAseq
82. NGS Data Analysis | Prediction of Multiple Myeloma Using RNASeq Data
81. NGS Data Analysis of Cancer Tissues | A Cancer Biology Study
79. Molecular Modeling study of Cyclophilin A and derivatives of Ganoderiol F (26,27-Dihydroxylanosta-7,9(11),24-trien-3-one): Design of novel inhibitors for CyclophilinA
78. Molecular Modeling study of derivates of Ethyl 2-[(4-chlorophenyl)carbamoylamino]-5-methyl-4-phenylthiophene-3-carboxylate and α-D-glucose-1-phosphate thymidylyltransferase (Mycobacterium-RmlA) | Discovery of new drugs for multidrug-resistant (MDR)Mtb
76. Molecular Modelling study of p53-MDM2 and derivatives of Ganoderiol F | Discovery of new Anti-CANCER Drugs by Molecular Docking & MD Simulations Approach
75. NGS Data Analysis on Alzheimer's
74. NGS Data Analysis on Cancer Biology | Analyzing cancer tissues
73. Inhibitory study of Focal Adhesion Kinase (FAK): A Virtual screening, Molecular Docking & ADMET study for combating cancer
72. Virtual Screening and Molecular Docking study of derivatives of chromen-2-one as selective Estrogen Receptor beta Agonists (SERBAs): Molecular Modeling study of Benign Prostatic Hyperplasia
71. Molecular Modeling Study of extracts of medicinal plants as potential anti-tubercular agents
70. Virtual screening & Molecular Docking of DOT1L & derivatives of Pinometostat | Molecular Modeling study of Therapeutic Target in Mixed-lineage Leukemia (MLL)
69. Targeting the Wnt/β-catenin signaling pathway in cancer by molecular modeling study of Ganoderiol F and Beta- Catenin
68. Biomarker discovery based on omics technology
67. Study of SARS-CoV-2 main protease (Mpro) and derivatives of Norterihanin to investigate potential inhibitors using Virtual Screening & Molecular Docking
66. Molecular Modelling study of SARS-CoV-2 spike protein of COVID-19 with derivatives of Saikosaponins | Examining the anticoronaviral activity of saikosaponins (A, B2, C and D)
65. Molecular Modeling study of Southeast Asian Medicinal Plant Aglaia erythrosperma and α-D-glucose-1-phosphate thymidylyltransferase (Mycobacterium-RmlA) | Discovery of new drugs for multidrug-resistant (MDR) Mtb
64.Molecular Modeling study of Cyclophilin A and derivatives of 1,8-Diamino-2,4,5,7-tetrachloroanthraquinone: Design of novel inhibitors for Cyclophilin A
63. Molecular Modelling study of Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis | Discovery of new Anti-Tubercular Drugs
62. Molecular Modelling study of p53-MDM2 | Discovery of new Anti-CANCER Drugs by Molecular Docking & MD Simulations Approach
61. Molecular modeling of sphingosine 1-phosphate receptor 1(S1P1) as target for multiple sclerosis | A Virtual screening, Molecular docking & ADMET study
60. Inhibitory study of α-D-glucose-1-phosphate thymidylyltransferase (Mycobacterium-RmlA) | Discovery of new drugs for multidrug-resistant (MDR) Mtb
59. Molecular modeling study of derivatives of dutasteride and Human Steroid 5β-Reductase (AKR1D1) | Discovery of new drugs for prostate cancer
57. Molecular modeling study of α-glucosidase Inhibitors (AGIs) | Discovery of new anti-diabetic drugs by controlling postprandial hyperglycemia
56. Discovery of new ligands for PPAR Gamma responsible for Diabetes Type 2: A Virtual Screening, Docking & ADMET Study.
53. Molecular Modelling study of phytoconstituents from medicinal plants of India | Discovery of natural anti-tubercular agents
49. Molecular Modeling study of Zika Virus | Virtual Screening, Protein Modeling, Docking, ADMET and MD Simulations Study
39. Study of derivatives of Chalcones as new Tyrosinase inhibitors: A Molecular Docking, ADME & Tox Study
34. Study of extracts of Veratrum Dahuricum as potential Anti-tumor molecules: Molecular Docking & Modeling study with Farnesyl Pyrophosphate Synthase (FFPS)